Featured publications
Publications
Selected peer-reviewed work from HEMERA-Lab. Open any article and ask questions about it — an AI assistant answers using the article record and its abstract, always citing the source.
- Rare diseasesMitochondrial metabolism2026
TfR1 deficiency beyond combined immunodeficiency. Pivotal role of mitochondrial function and iron-sulfur cluster biogenesis in disease pathogenesis
Loss of the transferrin receptor TfR1 disrupts mitochondrial function and iron-sulfur cluster assembly, explaining symptoms beyond immunodeficiency.
Muñoz-Pujol G, Huisman EJ, Mesa JF, Joosten M, Devos A, … Gort L, García-Villoria J, Fillat C, Tort F, Ribes A
Genes and Diseases
- GenomicsNeurodevelopment2025
Mutations in the small nuclear RNA gene RNU2-2 cause a severe neurodevelopmental disorder with prominent epilepsy
Variants in the small nuclear RNA gene RNU2-2 define a new severe neurodevelopmental disorder with prominent epilepsy.
Greene D, De Wispelaere K, Lees J, Codina-Solà M, Jensson BO, … Pérez-Jurado LA, Freson K, Mumford AD, Turro E
Nature Genetics
- NanozymesOxidative stress2025
Mesoporous silica-encapsulated cerium oxide nanozymes and quercetin for synergistic ROS-modulated downregulation of inflammatory cytokines
Cerium oxide nanozymes encapsulated in mesoporous silica plus quercetin act together to tune reactive oxygen species and lower inflammatory cytokines.
Zhou S, Zhang Y, Casals E, Zeng M, Morales-Ruiz M, Liu Q, Zhang B, Casals G
International Journal of Nanomedicine
- FibrosisLiver regeneration2023
Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humans
Tcf20 deficiency increases liver fibrogenesis and alters mitochondrial metabolism in both mouse models and patients.
Córdoba-Jover B, Ribera J, Portolés I, Lecue E, Rodriguez-Vita J, … Melgar-Lesmes P, Jiménez W, Morales-Ruiz M
Liver International
- MacrophagesNanomedicine2023
RNF41 orchestrates macrophage-driven fibrosis resolution and hepatic regeneration
RNF41 reprogrammes macrophages towards a reparative profile, resolving fibrosis and promoting hepatic regeneration.
Moreno-Lanceta A, Medrano-Bosch M, Fundora Y, Perramón M, Aspas J, … Jiménez W, Melgar-Lesmes P
Science Translational Medicine
- NanozymesMetabolic disease2021
Mesoporous silica coated CeO2 nanozymes with combined lipid-lowering and antioxidant activity induce long-term improvement of the metabolic profile in obese Zucker rats
Silica-coated CeO2 nanozymes combine lipid-lowering and antioxidant activity and improve the metabolic profile of obese rats long term.
Parra-Robert M, Zeng M, Shu Y, Fernandez-Varo G, Perramón M, … Jiménez W, Puntes V, Casals E, Casals G
Nanoscale
- NanomedicineFibrosis2021
Treatment of hepatic fibrosis in mice based on targeted plasmonic hyperthermia
Gold nanoparticles targeted to fibrotic liver tissue and activated by light deliver localised hyperthermia that reduces fibrosis in mice.
Ribera J, Vilches C, Sanz V, de Miguel I, Portolés I, … Jiménez W, Quidant R, Morales-Ruiz M
ACS Nano
- Liver cancerNanomedicine2020
Bespoken nanoceria: a new effective treatment in experimental hepatocellular carcinoma
Tailor-made nanoceria shows antitumour efficacy in experimental hepatocellular carcinoma.
Fernandez-Varo G, Perramón M, Carvajal S, Oro D, Casals E, … Puntes V, Jiménez W
Hepatology
- Liver regenerationSignalling2016
Akt-mediated Foxo1 inhibition is required for liver regeneration
Akt-driven inhibition of Foxo1 is a required step for the liver to regenerate after injury.
Pauta M, Rotllan N, Fernandez-Hernando A, Langhi C, Ribera J, … Morales-Ruiz M, Fernandez-Hernando C
Hepatology
- AngiogenesisVascular biology2014
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates
Endothelial Akt1 controls angiogenesis by phosphorylating several downstream angiogenic substrates.
Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, … Kyriakides TR, Morales-Ruiz M, Sessa WC
PNAS